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KMID : 0604520170430020165
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Journal of the Society of Cosmetic Scientists of Korea
2017 Volume.43 No. 2 p.165 ~ p.174
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Synthesis of Poly (lactide)-b-Poly (glycerol) (PLA-b-PG) Block Copolymer
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Lee John-Hwan
Oh Seong-Geun
Kim Yong-Jin
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Abstract
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This study reports a synthesis of an amphiphilic linear block copolymer consisting of a hydrophobic poly (lactide) (PLA) block and a hydrophilic hyperbranched polyglycerol (hbPG) block, PLA-b-hbPG. Simple chemical modification of the hbPG block with 4-hydroxycinnamic acid (CA) led to a photo-crosslinkable block copolymer, PLA-b-hbPG-CA. Nanosized micelles of the block copolyemrs were used as drug carriers for sustainable release. The hbPG shell made of a small molecular weight hbPG block showed excellent hydrophilicity, which can minimize in vivo toxicity. The UV-crosslinked PLA-b-hbPG-CA micelles loaded with drugs colud be served as a drug delivery carrier for its biocompatibility and self-assembled structures.
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KEYWORD
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hyperbranched polyglycerol , polymer synthesis , sustained release , amphiphilic block copolymer , drug delivery systems
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